Number of the records: 1
Relative deficiency of nitric oxide-dependent vasodilation in salt hypertensive Dahl rats: the possible role of superoxide anions
- 1.
SYSNO ASEP 0142122 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Relative deficiency of nitric oxide-dependent vasodilation in salt hypertensive Dahl rats: the possible role of superoxide anions Author(s) Zicha, Josef (FGU-C) RID, ORCID, SAI
Dobešová, Zdenka (FGU-C)
Kuneš, Jaroslav (FGU-C) RID, ORCIDSource Title Journal of Hypertension. - : Lippincott Williams & Wilkins - ISSN 0263-6352
Roč. 19, č. 2 (2001), s. 247-254Number of pages 8 s. Language eng - English Country US - United States Keywords blood pressure ; salt hypertension ; Dahl rats Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery R&D Projects IAA7011805 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA7011711 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LN00A069 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z5011922 - FGU-C Annotation The contribution of major vasoactive systems (renin-angiotensin system, sympathetic nervous system and nitric oxide) to blood pressure maintenance and the possible involvement of superoxide anions in the reduced efficiency of NO-dependent vasodilation to counterbalance sympathetic vasoconstriction were studied in salt hypertensive Dahl rats. It was demonstrated that NO system is not able to counterbalance effectively the hyperactivity of sympathetic nervous system in salt hypertensive Dahl rats. The predominance of sympathetic vasoconstriction over NO-dependent vasodilation could partially be explained by enhanced NO inactivation due to augmented superoxide anion formation in hypertensive animals. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2002
Number of the records: 1