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Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine

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    SYSNO ASEP0135983
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JOstatní články
    TitleAdenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine
    Author(s) Žurovec, Michal (ENTU-I)
    Doležal, Tomáš (ENTU-I)
    Gaži, Michal (ENTU-I)
    Pavlová, Eva (ENTU-I)
    Bryant, P. J. (US)
    Source TitleProceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences - ISSN 0027-8424
    Roč. 99, č. 7 (2002), s. 4403-4408
    Number of pages6 s.
    Languageeng - English
    CountryUS - United States
    Keywordsadenosine daminase ; minimal medium
    Subject RIVCE - Biochemistry
    R&D ProjectsGA204/01/1022 GA ČR - Czech Science Foundation (CSF)
    IAA5007107 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
    CEZAV0Z5007907 - ENTU-I, BC-A
    AnnotationWe describe a protein family in Drosophila containing six adenosine deaminase-related growth factors (ADGFs), which are homologous to a mitogenic growth factor discovered in conditioned medium from cells of a different fly species, Sarcophaga. Closely related proteins have been identified in other animals, and a human homolog is implicated in the genetic disease Cat-Eye Syndrome. The two most abundantly expressed ADGFs in Drosophila larvae are ADGF-A, which is strongly expressed in the gut and lymph glands, and ADGF-D, which is mainly expressed in the fat body and brain. Recombinant ADGF-A and ADGF-D are active adenosine deaminases (ADAs), and they cause polarization and serum-independent proliferation of imaginal disk and embryonic cells in vitro. The enzymatic activity of these proteins is required for their mitogenic function, making them unique among growth factors.
    WorkplaceInstitute of Entomology (until 2005)
    ContactHelena Musilová, musilova@entu.cas.cz, Tel.: 387 775 216
    Year of Publishing2004

Number of the records: 1  

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