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Comparative Analysis of the PDCD2-TBP-PSMB1 Region in Vertebrates
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SYSNO ASEP 0105328 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Comparative Analysis of the PDCD2-TBP-PSMB1 Region in Vertebrates Title Srovnávací analýza oblasti PDCD2-TBP-PSMB1 u obratlovců Author(s) Trachtulec, Zdeněk (UMG-J) RID, ORCID
Vlček, Čestmír (UMG-J) RID
Mihola, Ondřej (UMG-J) RID, ORCID
Forejt, Jiří (UMG-J) ORCID, RIDSource Title Gene. - : Elsevier - ISSN 0378-1119
Roč. 335, - (2004), s. 151-157Number of pages 7 s. Language eng - English Country NL - Netherlands Keywords Conserved synteny Subject RIV EB - Genetics ; Molecular Biology R&D Projects LN00A079 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GV204/98/K015 GA ČR - Czech Science Foundation (CSF) IAA5052709 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z5052915 - UMG-J Annotation Three orthologous genes encoding programmed cell death 2 (PDCD2), TATA-binding protein (TBP), and proteasomal subunit C5 (PSMB1) proteins have been shown previously to be nonrandomly distributed in both mammalian and invertebrate genomes. Here we analyze a conserved synteny of the PDCD2, TBP, and PSMB1 orthologs in four nonmammalian vertebrates. Homologous genes of the chicken, zebrafish, fugu, and Tetraodon nigroviridis were identified. A chicken cosmid harboring the orthologs of these three genes was completely sequenced. The fish genes were analyzed in silico. In all vertebrates thus far investigated, the PDCD2 and TBP genes were located tail-to-tail. In all species but the zebrafish, the PSMB1 gene mapped head-to-head or in the close vicinity to the TBP. A comparative analysis revealed the distribution of putative matrix-attached regions (MARs), which may affect the synteny conservation Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2005
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