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Segmental trisomy of mouse chromosome 17: introducing an alternative model of Down syndrome
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SYSNO ASEP 0105326 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Segmental trisomy of mouse chromosome 17: introducing an alternative model of Down syndrome Title Segmentální trizomie myšího chromozomu 17: seznámení s alternativním modelem Downova syndromu Author(s) Forejt, Jiří (UMG-J) RID, ORCID
Vacík, Tomáš (UMG-J) RID
Gregorová, Soňa (UMG-J)Source Title Comparative and Functional Genomics - ISSN 1531-6912
Roč. 4, - (2003), s. 647-652Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords segmental aneuploidy ; Down´s syndrome ; gene dosage Subject RIV EB - Genetics ; Molecular Biology R&D Projects LN00A079 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GV204/98/K015 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5052915 - UMG-J UT WOS 000187926900007 EID SCOPUS 0346505355 DOI 10.1002/cfg.334 Annotation All mouse models of human trisomy 21 syndrome that have been studied so far are based on segmental trisomies encompassing to a varying extent distal Chromosome (Chr) 16. Their comparison with one or more unrelated and non-overlapping segmental trisomies may help to distinguish the effects of specific triplicated genes from the phenotypes caused by less specific developmental instability mechanisms. In this paper the Ts43H segmental trisomy of the mouse Chr 17 is presented as such an alternative model. The trisomy stretches over 32.5 Mb of the proximal Chr 17 and includes 486 genes. The triplicated interval carries 7 blocks of syntenies with 5 human chromosomes. The block syntenic to human Chr 21 contains 20 genes Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2005
Number of the records: 1