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Synthesis of (2E)-2-Methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)prop-2-enoic acid (VUFB 20609) and 2-Methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propanoic acid (VUFB 20584) as Potential Antileukotrienic Agents
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SYSNO ASEP 0104804 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Synthesis of (2E)-2-Methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)prop-2-enoic acid (VUFB 20609) and 2-Methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propanoic acid (VUFB 20584) as Potential Antileukotrienic Agents Title Syntéza (2E)-2-methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)pr op-2-enové kyseliny (VUFB 20609) and 2-methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propanové kyseliny (VUFB 20584) jakožto potenciálních antileukotrienických látek Author(s) Jampílek, J. (CZ)
Doležal, M. (CZ)
Kuneš, J. (CZ)
Víchová, P. (CZ)
Jun, D. (CZ)
Hanika, Jiří (UCHP-M) RID, ORCID, SAI
O´Connor, R. (IE)
Clynes, M. (IE)Source Title Journal of Pharmacy and Pharmacology - ISSN 0022-3573
Roč. 56, č. 6 (2004), s. 783-794Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords aryl iodides ; amarium-diodide ; leukotrienes Subject RIV CI - Industrial Chemistry, Chemical Engineering CEZ AV0Z4072921 - UCHP-M Annotation The syntheses of (2E)-2-methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl) prop-2-enoic acid (VUFB 20609) and racemic 2-methyl-3-(4-{[4-(quinolin-2-ylmethoxy) phenyl]sulfanyl}phenyl)propanoic acid (VUFB 20584) as new potential antileukotrienic drugs are described. Due to a low reactivity of the 4-substituted aryl bromides (coupling of the 4-substituted aryl bromides do not provide an activating functional group with 4-methoxybenzene-1-thiol), special conditions, in particular specific heterogeneous copper catalysts, were used. Catalytic hydrogenation of the conjugated double bond on Pd/C in the presence of the sulfanyl group is discussed. In-vitro cytotoxicity testing was performed using a microplate colorimetric acid phosphatase assay. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2005
Number of the records: 1