Toxicity of hydroxylated and quinoid PCB metabolites: Inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells

Machala, M.; Bláha, L.; Lehmler, H.-J.; Plíšková, M.; Májková, Z.; Kapplová, P.; Sovadinová, I.; Vondráček, Jan; Malmberg, T.; Robertson, L. W.

Number of the records: 1

Toxicity of hydroxylated and quinoid PCB metabolites: Inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells

1.

SYSNO ASEP	0104662
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	Toxicity of hydroxylated and quinoid PCB metabolites: Inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells
Title	Toxicita hydroxylovaných PCB a PCB chinonů: Inhibice mezibuněčné komunikace typu “gap junction” a aktivace receptoru pro aromatické uhlovodíky a estrogenního receptoru v jaterních a prsních buňkách
Author(s)	Machala, M. (CZ) Bláha, L. (CZ) Lehmler, H.-J. (US) Plíšková, M. (CZ) Májková, Z. (CZ) Kapplová, P. (CZ) Sovadinová, I. (CZ) Vondráček, Jan (BFU-R)_{RID, ORCID} Malmberg, T. (SE) Robertson, L. W. (US)
Source Title	Chemical Research in Toxicology - ISSN 0893-228X Roč. 17, č. 3 (2004), s. 340-347
Number of pages	8 s.
Language	eng - English
Country	US - United States
Keywords	hydroxylated polychlorinated biphenyls ; AhR-mediated activity ; inhibition of GJIC
Subject RIV	BO - Biophysics
R&D Projects	QC0194 GA MZe - Ministry of Agriculture (MZe)
	IPP1050128 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z5004920 - BFU-R
Annotation	In the present study a series of thirty-two hydroxy and dihydroxy-PCBs (OH-PCBs) and PCB-derived quinones were prepared and evaluated for their in vitro potencies to downregulate gap junctional intercellular communication (GJIC) and to activate the aryl hydrocarbon receptor (AhR) and the estrogen receptor in liver and mammary cell models. The results show that oxygenated PCB metabolites are capable of multiple adverse effects, including gap junction inhibition, AhR-mediated activity and (anti)estrogenicity. The inhibition of GJIC by OH-PCBs represents a novel mode of action of both the lower-chlorinated and the persisting high-molecular-weight OH-PCBs.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2005

Number of the records: 1