A constitutively active cryptochrome in Drosophila melanogaster

Number of the records: 1

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SYSNO ASEP	0100929
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	A constitutively active cryptochrome in Drosophila melanogaster
Title	Konstitutivně aktivní cryptochrom u octomilky, Drosophila melanogaster
Author(s)	Dissel, S. (GB) Codd, V. (GB) Fedič, Robert (ENTU-I) Garner, K. J. (GB) Costa, R. (IT) Kyriacou, C. P. (GB) Rosato, E. (GB)
Source Title	Nature Neuroscience. - : Nature Publishing Group - ISSN 1097-6256 Roč. 7, č. 8 (2004), s. 834-840
Number of pages	7 s.
Language	eng - English
Country	US - United States
Keywords	Circadian clock ; behavioral rhythms ; light
Subject RIV	ED - Physiology
R&D Projects	KSK5052113 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
Annotation	Light-activated cryptochrome (CRY) regulates circadian photoresponses in Drosophila melanogaster. Removing the carboxy (C) terminus to create CRYDelta produces, in yeast, a light-independent, constitutively active form. Here we show that flies overexpressing CRYDelta have a longer free-running period of locomotor activity, as well as altered cycling kinetics of the clock proteins timeless (TIM) and period (PER)
Workplace	Institute of Entomology (until 2005)
Contact	Helena Musilová, musilova@entu.cas.cz, Tel.: 387 775 216
Year of Publishing	2005

Number of the records: 1