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Chromosomal rearrangement interferes with meiotic X chromosome inactivation
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SYSNO ASEP 0090940 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Chromosomal rearrangement interferes with meiotic X chromosome inactivation Title Chromozomální přestavba interferuje s meiotickou inaktivací chromozomu X Author(s) Homolka, David (UMG-J)
Ivánek, Robert (UMG-J)
Čapková, Jana (UMG-J)
Jansa, Petr (UMG-J) RID
Forejt, Jiří (UMG-J) RID, ORCIDSource Title Genome Research. - : Cold Spring Harbor Laboratory Press - ISSN 1088-9051
Roč. 17, č. 10 (2007), s. 1431-1437Number of pages 7 s. Language eng - English Country US - United States Keywords chromosomal translocations ; meiotic X chromosome inactivation ; spermatogenesis Subject RIV EB - Genetics ; Molecular Biology R&D Projects 1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA301/06/1334 GA ČR - Czech Science Foundation (CSF) GA301/07/1383 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) Annotation Heterozygosity for certain mouse and human chromosomal rearrangements is characterized by the incomplete meiotic synapsis of rearranged chromosomes, by their colocalization with the XY body in primary spermatocytes, and by male-limited sterility. Here, we report on the transcriptional down-regulation of genes within the unsynapsed region of the rearranged mouse chromosome 17, and on the subsequent disturbance of X chromosome inactivation. The partial transcriptional suppression of genes in the unsynapsed chromatin was most prominent prior to the mid-pachytene stage of primary spermatocytes. Later, during the mid-late pachytene, the rearranged autosomes colocalized with the XY body, and the X chromosome failed to undergo proper transcriptional silencing. Our findings provide direct evidence on the MSUC acting at the mRNA level, and implicate that autosomal asynapsis in meiosis may cause male sterility by interfering with meiotic sex chromosome inactivation. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2008
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