Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins
1.
SYSNO ASEP
0051159
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins
Title
Molekulární mechanismus apoptózy indukované ´mitokany´ v rakovinných buňkách shrnuje vícenásobnou roli reaktivních kyslíkových druhů a proteinů rodiny Bcl-2
Author(s)
Neužil, Jiří (UMG-J) Wang, X.F. (AU) Dong, L.F. (AU) Low, P. (AU) Ralph, S.J. (AU)
Source Title
FEBS Letters. - : Wiley
- ISSN 0014-5793
Roč. 580, č. 22 (2006), s. 5125-5129
Number of pages
5 s.
Language
eng - English
Country
GB - United Kingdom
Keywords
mitocan ; alpha-tocopheryl succinate ; reactive oxygen species
Subject RIV
EB - Genetics ; Molecular Biology
CEZ
AV0Z50520514 - UMG-J (2005-2011)
Annotation
Mitochondria have emerged recently as effective targets for novel anti-cancer drugs referred to as "mitocans". We propose that the molecular mechanism of induction of apoptosis by mitocans, as exemplified by the drug alpha-tocopheryl succinate, involves generation of reactive oxygen species (ROS). ROS then mediate the formation of disufide bridges between cytosolic Bax monomers, resulting in the formation of mitochondrial outer membrane channels. ROS also cause oxidation of cardiolipin, triggering the release of cytochrome c and its translocation via the activated Bax channels. This model may provide a general mechanism for the action of inducers of apoptosis and anticancer drugs, mitocans, targeting mitochondria via ROS production.
