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Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions
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SYSNO ASEP 0043437 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions Title Proteasy z Candidy albicans zakotvené k buněčné membráně nebo buněčné stěně glykosylfosfatidylovou kotvou jsou nezbytné pro buněčné procesy a interakci mezi patogenem a hostitelem Author(s) Albrecht, A. (DE)
Felk, A. (DE)
Pichová, Iva (UOCHB-X) RID, ORCID
Naglik, J. R. (GB)
Schaller, M. (DE)
Groot de, P. (NL)
MacCallum, D. (GB)
Odds, F. C. (GB)
Schäfer, W. (DE)
Klis, F. (NL)
Monod, M. (CH)
Hube, B. (DE)Source Title Journal of Biological Chemistry. - : Elsevier - ISSN 0021-9258
Roč. 281, č. 2 (2006), s. 688-694Number of pages 7 s. Language eng - English Country US - United States Keywords GPL ; SAP ; GFP ; BEC Subject RIV CE - Biochemistry R&D Projects GA303/04/0432 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) Annotation Here we describe aspartic proteases Sap9 and Sap10 of Candida albicans, which have structural similarities to yapsins of Saccharomyces cerevisiae. Sap9 and Sap10 are located in the cell membrane or the cell wall. Both proteases are glycosylated, cleave at dibasic or basic processing sites, and have functions in cell surface integrity and cell separation during budding. Deletion of SAP9 and SAP10 genes modified the adhesion properties of C. albicans to epithelial cells. These proteases have a unique role in cellular processes and host-pathogen interactions. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2007
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