IAA6022306 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ
AV0Z60220518 - PAU-O, BC-A (2005-2011)
Annotation
Ixodes ricinus L. is the principal European vector of Borrelia burgdorferi sensu lato, the causative agent of Lyme borreliosis. Subtractive hybridization was used to isolate tick genes that were induced in whole ticks after blood meals on uninfected and B. burgdorferi-infected guinea pigs. Novel cDNA clones with similarity to cytochrome c oxidase, salivary secreted protein, acetin, and a cysteine protease propeptide were induced after a blood meal. Novel cDNA clones with similarity to thiredoxin peroxidases, dolichyl-phosphate beta-glucosyltransferase, glutathion S-transferase, defensin, ML domain-containing protein, and Willebrand factor were induced after B. burgdorferi infection.
