Metal Exchange Reactions in Metallothioneins Explored by Electrochemical Methods

0510095 - ÚFCH JH 2020 RIV DE eng J - Journal Article
Šestáková, Ivana - Navrátil, Tomáš - Josypčuk, Bohdan
Metal Exchange Reactions in Metallothioneins Explored by Electrochemical Methods.
Electroanalysis. Roč. 2019, č. 10 (2019), s. 2020-2023. ISSN 1040-0397. E-ISSN 1521-4109
R&D Projects: GA ČR GA17-03868S
Institutional support: RVO:61388955
Keywords : voltammetric determination * mercury * carbon * chronopotentiometry * phytochelatins * complexation * electrodes * cadmium * domain * cd * Metallothioneins
OECD category: Physical chemistry
Impact factor: 2.544, year: 2019
Method of publishing: Limited access

Metallothioneins (MTs) are widely occurring, small, cysteine-rich proteins, important for essential metal (Zn, Cu) homeostasis and transport and for heavy metal (Cd, Hg) detoxification. In buffered solutions of mammalian MT, voltammetry and potentiometric striping analysis (PSA) can distinguish different coordination of bound metals or follow their exchange, especially that of zinc and cadmium for copper, silver, and cobalt. The examples of different electrode applications as of hanging mercury drop electrode (HMDE), of silver solid amalgam (AgSAE) electrode, and of silica gel modified carbon paste electrode (SiO2-CPE) are given.
Permanent Link: http://hdl.handle.net/11104/0300650