The role of gut microbiota in intestinal and liver diseases

0507943 - MBÚ 2020 RIV US eng J - Journal Article
Hrnčíř, Tomáš - Hrnčířová, Lucia - Kverka, Miloslav - Tlaskalová-Hogenová, Helena
The role of gut microbiota in intestinal and liver diseases.
Laboratory Animals. Roč. 53, č. 3 (2019), s. 271-280. ISSN 0023-6772. E-ISSN 1758-1117
R&D Projects: GA ČR(CZ) GA15-09518S; GA ČR(CZ) GA15-07268S; GA ČR(CZ) GA16-06326S; GA ČR(CZ) GA17-07332S; GA ČR(CZ) GA17-09869S; GA MZd(CZ) NV15-28064A; GA MZd(CZ) NV15-30782A; GA MZd NV17-31248A
Institutional support: RVO:61388971
Keywords : inflammatory bowel disease * cancer * coeliac disease
OECD category: Immunology
Impact factor: 1.495, year: 2019
Method of publishing: Limited access
https://journals.sagepub.com/doi/10.1177/0023677218818605

The world-wide incidence of many immune-mediated and metabolic diseases, including those of the intestines and liver, is steadily increasing. Gut microbiota plays a central role in the pathogenesis of these diseases as it mediates environmental changes to the intestinal immune system. Various environmental factors including diet, food additives and medication also trigger the compositional and functional alterations of microbiota, that is, dysbiosis, and this dysbiosis is closely associated with many chronic inflammatory diseases. However, the causal relationship remains unclear for the majority of these diseases. In this review, we discuss essential epidemiological data, known pathogenetic factors including those of genetic and environmental nature, while mainly focusing on the role of gut microbiota in the development of selected intestinal and liver diseases. Using specific examples, we also briefly describe some of the most widely-used animal models including gnotobiotic models and their contribution to the research of pathogenetic mechanisms of the host-microbiota relationship.
Permanent Link: http://hdl.handle.net/11104/0298909