Optimal Tolerogenic Dendritic Cells in Type 1 Diabetes (T1D) Therapy: What Can We Learn From Non-obese Diabetic (NOD) Mouse Models?

0505825 - MBÚ 2020 RIV CH eng J - Journal Article
Funda, David P. - Palová-Jelinková, L. - Goliáš, Jaroslav - Kroulíková, Zuzana - Fajstová, Alena - Hudcovic, Tomáš - Spíšek, R.
Optimal Tolerogenic Dendritic Cells in Type 1 Diabetes (T1D) Therapy: What Can We Learn From Non-obese Diabetic (NOD) Mouse Models?
Frontiers in Immunology. Roč. 10, MAY 14 (2019), č. článku 967. ISSN 1664-3224. E-ISSN 1664-3224
R&D Projects: GA MZd(CZ) NV16-27994A
Institutional support: RVO:61388971
Keywords : type 1 diabetes * cell therapy * animal models
OECD category: Microbiology
Impact factor: 5.085, year: 2019
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fimmu.2019.00967/full

Tolerogenic dendritic cells (tolDCs) are explored as a promising standalone or combination therapy in type 1 diabetes (T1D). The therapeutic application of tolDCs, including in human trials, has been tested also in other autoimmune diseases, however, T1D displays some unique features. In addition, unlike in several disease-induced animal models of autoimmune diseases, the prevalent animal model for T1D, the NOD mouse, develops diabetes spontaneously. This review compares evidence of various tolDCs approaches obtained from animal (mainly NOD) models of T1D with a focus on parameters of this cell-based therapy such as protocols of tolDC preparation, antigen-specific vs. unspecific approaches, doses of tolDCs and/or autoantigens, application schemes, application routes, the migration of tolDCs as well as their preventive, early pre-onset intervention or curative effects. This review also discusses perspectives of tolDC therapy and areas of preclinical research that are in need of better clarification in animal models in a quest for effective and optimal tolDC therapies of T1D in humans.
Permanent Link: http://hdl.handle.net/11104/0297201