Effect of nanodiamond particles on neuronal tissue

0500088 - MBÚ 2019 RIV CZ eng C - Conference Paper (international conference)
Šimková, Veronika - Benson, Veronika
Effect of nanodiamond particles on neuronal tissue.
IMBM 2018 Proceedings. Kladno: FBMI ČVUT, 2018 - (Pánek, D.; Parkman, J.), s. 59-61. ISBN 978-80-01-06502-0.
[Instruments and Methods for Biology and Medicine 2018. Kladno (CZ), 10.05.2018-10.05.2018]
Institutional support: RVO:61388971
Keywords : nanodiamonds * cell cytoplasm * neuronal tissue
OECD category: Microbiology

High-Pressure High-Temperature nanodiamonds are considered to be highly biocompatible due to
their low acute toxicity, which makes them suitable for biomedical applications. However, next to interaction with the cell membrane, nanoscale allows particles to penetrate the plasma membrane and even accumulate in the cell cytoplasm. Recently it brought up questions regarding sustainable nanoparticle application in vivo and potential toxicity hazards. The neuronal tissue consists of neurons and glial cells, and it is separated by a bloodbrain barrier from the peripheral blood system. Neurons are nerve cells forming a complex network of synapses that carry signals in the brain. The neurons are nourished and protected by glial cells. This project aims to find out whether nanodiamonds pass the blood-brain barrier when applied intravenously as a drug carrier and whether they directly interact with the neuronal tissue.
Permanent Link: http://hdl.handle.net/11104/0292238