Comment on 'Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death'

0499460 - MBÚ 2019 RIV US eng J - Journal Article
Aouacheria, A. - Cunningham, K.W. - Hardwick, J.M. - Palková, Z. - Powers, T. - Severin, F.F. - Váchová, Libuše
Comment on 'Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death'.
Science. Roč. 360, č. 6395 (2018), č. článku eaar6910. ISSN 0036-8075. E-ISSN 1095-9203
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:61388971
Keywords : structural basis * inhibition * growth
OECD category: Microbiology
Impact factor: 41.063, year: 2018
Method of publishing: Limited access
https://www.science.org/doi/10.1126/science.aar6910

Shlezinger et al. (Reports, 8 September 2017, p. 1037) report that the common fungus Aspergillus fumigatus, a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies they used do not provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by a fungal caspase inhibitor homologous to human survivin.
Permanent Link: http://hdl.handle.net/11104/0291670