Impact of GM(1) on Membrane-Mediated Aggregation/Oligomerization of beta-Amyloid: Unifying View

0478167 - ÚFCH JH 2018 RIV US eng J - Journal Article
Cebecauer, Marek - Hof, Martin - Amaro, Mariana
Impact of GM(1) on Membrane-Mediated Aggregation/Oligomerization of beta-Amyloid: Unifying View.
Biophysical Journal. Roč. 113, č. 6 (2017), s. 1194-1199. ISSN 0006-3495. E-ISSN 1542-0086
R&D Projects: GA ČR GA17-03160S
Institutional support: RVO:61388955
Keywords : SURFACE-PLASMON RESONANCE * ALZHEIMERS-DISEASE * GM1 GANGLIOSIDE
OECD category: Biophysics
Impact factor: 3.495, year: 2017
Method of publishing: Open access

In this perspective we summarize current knowledge of the effect of monosialoganglioside GM(1) on the membrane-mediated aggregation of the beta-amyloid (A beta) peptide. GM(1) has been suggested to be actively involved in the development of Alzheimer's disease due to its ability to seed the aggregation of A beta. However, GM(1) is known to be neuroprotective against A beta-induced toxicity. Here we suggest that the two scenarios are not mutually exclusive but rather complementary, and might depend on the organization of GM(1) in membranes. Improving our understanding of the molecular details behind the role of gangliosides in neurodegenerative amyloidoses might help in developing disease-modifying treatments.
Permanent Link: http://hdl.handle.net/11104/0274355