Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2

0173739 - UEM-P 20033062 RIV US eng J - Journal Article
Bryja, Vítězslav - Sedláček, J. - Zahradníčková, E. - Ševčíková, S. - Pacherník, J. - Souček, K. - Hofmanová, J. - Kozubík, A. - Šmarda, J.
Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2.
Prostaglandins & Other Lipid Mediators. Roč. 72, - (2003), s. 131-145. ISSN 1098-8823. E-ISSN 2212-196X
R&D Projects: GA ČR GA301/01/0040; GA ČR GA524/03/0766
Institutional research plan: CEZ:AV0Z5039906; CEZ:MSM 14300008
Keywords : hematopoiesis
Subject RIV: EB - Genetics ; Molecular Biology

In this study lipoxygenase inhibitors were used to study the role of arachidonic acid metabolism in regulation of proliferation and apoptosis of chicken monoblasts BM2 and its functional interaction with Jun proteins. It was demonstrated that lipoxygenase inhibitors further enforce tumor suppresive capabilities of Jun proteins by inducing either more efficient cell cycle block and/or apoptosis in BM2 cells. This suggests that there is a crosstalk between the lipoxygenase- and Jun-directed pathways in regulation of proliferation and differentiation of leukemic cells.
Permanent Link: http://hdl.handle.net/11104/0070765