Current Approaches to Wound Repair in Burns: How far we Have Come From Cover to Close? A Narrative Review

0583345 - FGÚ 2025 RIV NL eng J - Journal Article
Šuca, H. - Čoma, M. - Tomšů, Júlia - Sabová, J. - Zajíček, R. - Brož, Antonín - Doubková, Martina - Novotný, T. - Bačáková, Lucie - Jenčová, V. - Kuželová Košťáková, E. - Lukačín, Š. - Rejman, Dominik - Gál, P.
Current Approaches to Wound Repair in Burns: How far we Have Come From Cover to Close? A Narrative Review.
Journal of Surgical Research. Roč. 296, April (2024), s. 383-403. ISSN 0022-4804. E-ISSN 1095-8673
R&D Projects: GA MZd(CZ) NU22-06-00016; GA MŠMT(CZ) LX22NPO5103; GA ČR(CZ) GA22-08857S
Grant - others:AV ČR(CZ) AP2202
Program: Akademická prémie - Praemium Academiae
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : regeneration * scar * skin * wound dressing * wound healing
OECD category: Cell biology
Impact factor: 2.2, year: 2022
https://doi.org/10.1016/j.jss.2023.12.043

Burn injuries are a significant global health concern, with more than 11 million people requiring medical intervention each year and approximately 180,000 deaths annually. Despite progress in health and social care, burn injuries continue to result in socioeconomic burdens for victims and their families. The management of severe burn injuries involves preventing and treating burn shock and promoting skin repair through a two-step procedure of covering and closing the wound. Currently, split-thickness/full-thickness skin autografts are the gold standard for permanent skin substitution. However, deep burns treated with split-thickness skin autografts may contract, leading to functional and appearance issues. Conversely, defects treated with full-thickness skin autografts often result in more satisfactory function and appearance. The development of tissue-engineered dermal templates has further expanded the scope of wound repair, providing scar reductive and regenerative properties that have extended their use to reconstructive surgical interventions. Although their interactions with the wound microenvironment are not fully understood, these templates have shown potential in local infection control. This narrative review discusses the current state of wound repair in burn injuries, focusing on the progress made from wound cover to wound closure and local infection control. Advancements in technology and therapies hold promise for improving the outcomes for burn injury patients. Understanding the underlying mechanisms of wound repair and tissue regeneration may provide new insights for developing more effective treatments in the future.
Permanent Link: https://hdl.handle.net/11104/0351322