Tannic acid- and N-acetylcysteine-chitosan-modified magnetic nanoparticles reduce hepatic oxidative stress in prediabetic rats

0582515 - ÚMCH 2025 RIV NL eng J - Journal Article
Swietek, Malgorzata Anna - Marková, I. - Malínská, H. - Hüttl, M. - Miklánková, D. - Černá, K. - Konefal, Rafal - Horák, Daniel
Tannic acid- and N-acetylcysteine-chitosan-modified magnetic nanoparticles reduce hepatic oxidative stress in prediabetic rats.
Colloids and Surfaces B-Biointerfaces. Roč. 235, March (2024), č. článku 113791. ISSN 0927-7765. E-ISSN 1873-4367
R&D Projects: GA MŠMT LX22NPO5102
Institutional support: RVO:61389013
Keywords : magnetic * nanoparticles * chitosan, N-acetylcysteine
OECD category: Polymer science
Impact factor: 5.8, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0927776524000493?via%3Dihub

Magnetic nanoparticles (MNPs) modified with tannic acid (TA) have shown remarkable success as an antioxidant and antimicrobial therapeutic agent. Herein, we report a synthetic procedure for the preparation of silica-coated MNPs modified with N-acetylcysteine-modified chitosan and TA. This was achieved by free-radical grafting of NAC onto chitosan (CS), a layer-by-layer technique for modifying negatively charged MNP@SiO2 nanoparticles with positively charged CS-NAC, and crosslinking CS with TA. The antioxidant and metabolic effects of MNP@SiO2-CS-NAC and MNP@SiO2-CS-NAC-TA nanoparticles were tested in a model of prediabetic rats with hepatic steatosis, the hereditary hypertriglyceridemic rats (HHTg). The particles exhibited significant antioxidant properties in the liver, increasing the activity of the antioxidant enzymes superoxide dismutase (SOD), glutathione reductase (GR) and glutathione peroxidase (GPx), decreasing the concentration of the lipoperoxidation product malondialdehyde (MDA), and improving the antioxidant status determined as the ratio of reduced to oxidized glutathione, in particular, TA increased some antioxidant parameters. MNPs carrying antioxidants such as NAC and TA could thus represent a promising therapeutic agent for the treatment of various diseases accompanied by increased oxidative stress.
Permanent Link: https://hdl.handle.net/11104/0350590