Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells

0580369 - ÚEM 2024 RIV GB eng J - Journal Article
Echalar, Barbora - Dostálová, Dominika - Palacká, Kateřina - Javorková, Eliška - Heřmánková, Barbora - Červená, Tereza - Zajícová, Alena - Holáň, Vladimír - Rössner ml., Pavel
Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells.
Toxicology in Vitro. Roč. 87, mar (2023), č. článku 105536. ISSN 0887-2333. E-ISSN 1879-3177
R&D Projects: GA ČR(CZ) GA21-17720S
Institutional support: RVO:68378041
Keywords : metal nanoparticles * mesenchymal stem cells * dose-dependent toxicity * gene expression * cytokine production
OECD category: Cell biology
Impact factor: 3.2, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/abs/pii/S088723332200234X?via%3Dihub

Nanoparticles (NPs) have a wide use in various field of industry and in medicine, where they represent a promise for their antimicrobial effects. Simultaneous application of NPs and therapeutic stem cells can speed up tissue regeneration and improve healing process but there is a danger of negative impacts of NPs on stem cells. Therefore, we tested effects of four types of metal antimicrobial NPs on characteristics and function properties of mouse mesenchymal stem cells (MSCs) in vitro. All types of tested NPs, i.e. zinc oxide, silver, copper oxide and titanium dioxide, exerted negative effects on the expression of phenotypic markers, metabolic activity, differ-entiation potential, expression of genes for immunoregulatory molecules and on production of cytokines and growth factors by MSCs. However, there were apparent differences in the impact of individual types of NPs on tested characteristics and function properties of MSCs. The results showed that individual types of NPs influence the activity of MSCs, and thus the use of metal NPs during tissue regeneration and in combination with stem cell therapy should be well considered.
Permanent Link: https://hdl.handle.net/11104/0351053