0576568 - BC 2024 RIV NL eng J - Journal Article
Hajdušek, Ondřej - Kopáček, Petr - Perner, Jan
Experimental platforms for functional genomics in ticks.
Current Opinion in Insect Science. Roč. 59, OCT (2023), č. článku 101102. ISSN 2214-5745. E-ISSN 2214-5753
R&D Projects: GA ČR(CZ) GM22-18424M; GA ČR(CZ) GA21-08826S; GA ČR(CZ) GC22-12648J
Institutional support: RVO:60077344
Keywords : Tick * genomics * CRISPR–Cas9
OECD category: Biochemistry and molecular biology
Impact factor: 5.8, year: 2023
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S2214574523000998?via%3Dihub

Ticks are blood-feeding ectoparasites that devastate cattle farming and are an omnipresent nuisance to pets and humans, posing a threat of pathogen transmission. Laboratory experimental models can be instrumental in the search for molecular targets of novel acaricides or vaccines. Mainly, though, the experimental models represent invaluable tools for broadening our basic understanding of key processes of tick blood-feeding physiology and vector competence. In order to understand the function of a single component within the full complexity of a feeding tick, genetic or biochemical interventions are used for systemic phenotypisation. In this work, we summarise current experimental modalities that represent powerful approaches for determining biological functions of tick molecular components.
Permanent Link: https://hdl.handle.net/11104/0346302