0576496 - BC 2024 RIV GB eng J - Journal Article
Contreras, M. - Vaz-Rodrigues, R. - Mazuecos, L. - Villar, M. - Artigas-Jerónimo, S. - Gonzalez-Garcia, A. - Shilova, N.V. - Bovin, N.V. - Diaz-Sanchez, S. - Ferreras-Colino, E. - Pacheco, I. - Chmelař, J. - Kopáček, Petr - Cabezas-Cruz, A. - Gortazar, C. - de la Fuente, J.
Allergic reactions to tick saliva components in zebrafish model.
Parasites & Vectors. Roč. 16, č. 1 (2023), č. článku 242. ISSN 1756-3305. E-ISSN 1756-3305
Institutional support: RVO:60077344
Keywords : Allergy * Alpha-gal syndrome * Glycan * Tick * Zebrafish
OECD category: Tropical medicine
Impact factor: 3, year: 2023 ; AIS: 0.838, rok: 2023
Method of publishing: Open access
Result website:
https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-023-05874-2DOI: https://doi.org/10.1186/s13071-023-05874-2

Background Alpha-Gal syndrome (AGS) is a tick-borne food allergy caused by IgE antibodies against the glycan galactose-alpha-1,3-galactose (a-Gal) present in glycoproteins and glycolipids from mammalian meat. To advance in the diagnosis and treatment of AGS, further research is needed to unravel the molecular and immune mechanisms underlying this syndrome. The objective of this study is the characterization of tick salivary components and proteins with and without alpha-Gal modifications involved in modulating human immune response against this carbohydrate.
Permanent Link: https://hdl.handle.net/11104/0346050