Hypertension after the Menopause: What Can We Learn from Experimental Studies?

0574955 - FGÚ 2024 RIV CZ eng J - Journal Article
Piťha, J. - Vaněčková, Ivana - Zicha, Josef
Hypertension after the Menopause: What Can We Learn from Experimental Studies?
Physiological Research. Roč. 72, Suppl.2 (2023), s. 91-112. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LX22NPO5104
Institutional support: RVO:67985823
Keywords : hypertension * sex differences * menopause * ovariectomy * timing of treatment * experimental models
OECD category: Cardiac and Cardiovascular systems
Impact factor: 2.1, year: 2022
Method of publishing: Open access
https://www.biomed.cas.cz/physiolres/pdf/2023/72_S91.pdf

Hypertension is the most prevalent cardiovascular disease of the adult population and is closely associated with serious cardiovascular events. The burden of hypertension with respect to vascular and other organ damage is greater in women. These sex differences are not fully understood. The unique feature in women is their transition to menopause accompanied by profound hormonal changes that affect the vasculature that are also associated with changes of blood pressure. Results from studies of hormone replacement therapy and its effects on the cardiovascular system are controversial, and the timing of treatment after menopause seems to be important. Therefore, revealing potential sex-and sex hormone-dependent pathophysiological mechanisms of hypertension in experimental studies could provide valuable information for better treatment of hypertension and vascular impairment, especially in postmenopausal women. The experimental rat models subjected to ovariectomy mimicking menopause could be useful tools for studying the mechanisms of blood pressure regulation after menopause and during subsequent therapy.
Permanent Link: https://hdl.handle.net/11104/0344879