The role of GABAB receptors in the subcortical pathways of the mammalian auditory system

0574202 - ÚEM 2024 RIV CH eng J - Journal Article
Tureček, Rostislav - Melichar, Adolf - Králíková, Michaela - Hrušková, Bohdana
The role of GABAB receptors in the subcortical pathways of the mammalian auditory system.
Frontiers in Endocrinology. Roč. 14, aug. (2023), č. článku 1195038. ISSN 1664-2392. E-ISSN 1664-2392
R&D Projects: GA MŠMT(CZ) LX22NPO5107; GA ČR(CZ) GA21-17085S
Institutional support: RVO:68378041
Keywords : GABAB receptor * auditory * Synaptic Transmission * Neuronal excitability * Hearing Loss * Tinnitus
OECD category: Neurosciences (including psychophysiology
Impact factor: 5.2, year: 2022
Method of publishing: Open access
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1195038/full

GABAB receptors are G-protein coupled receptors for the inhibitory neurotransmitter GABA. Functional GABAB receptors are formed as heteromers of GABAB1 and GABAB2 subunits, which further associate with various regulatory and signaling proteins to provide receptor complexes with distinct pharmacological and physiological properties. GABAB receptors are widely distributed in nervous tissue, where they are involved in a number of processes and in turn are subject to a number of regulatory mechanisms. In this review, we summarize current knowledge of the cellular distribution and function of the receptors in the inner ear and auditory pathway of the mammalian brainstem and midbrain. The findings suggest that in these regions, GABAB receptors are involved in processes essential for proper auditory function, such as cochlear amplifier modulation, regulation of spontaneous activity, binaural and temporal information processing, and predictive coding. Since impaired GABAergic inhibition has been found to be associated with various forms of hearing loss, GABAB dysfunction could also play a role in some pathologies of the auditory system.
Permanent Link: https://hdl.handle.net/11104/0344550