Thermoresponsive triblock copolymers as widely applicable 19F magnetic resonance imaging tracers

0565996 - ÚMCH 2023 RIV US eng J - Journal Article
Kolouchová, K. - Groborz, Ondřej - Šlouf, Miroslav - Herynek, V. - Parmentier, L. - Babuka, David - Černochová, Zulfiya - Koucký, F. - Sedláček, O. - Hrubý, Martin - Hoogenboom, R. - van Vlierberghe, S.
Thermoresponsive triblock copolymers as widely applicable 19F magnetic resonance imaging tracers.
Chemistry of Materials. Roč. 34, č. 24 (2022), s. 10902-10916. ISSN 0897-4756. E-ISSN 1520-5002
R&D Projects: GA TA ČR(CZ) TO01000074
Research Infrastructure: Czech-BioImaging II - 90129
Institutional support: RVO:61389013
Keywords : physically crosslinked hydrogels * BAB block copolymers * fluorine-19 magnetic resonance imaging
OECD category: Polymer science
Impact factor: 8.6, year: 2022
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.chemmater.2c02589

Fluorine-19 magnetic resonance imaging (19F MRI) has emerged as a promising noninvasive diagnostic tool, broadening the diagnostic possibilities of commonly used proton MRI. Despite the potential of 19F MRI, an ideal tracer paving the way toward the entry of this method into common medical practice is yet to be developed. In this study, we report on a series of polymeric systems based on thermoresponsive poly[N-(2,2-difluoroethyl)acrylamide] (PDFEA), a polymer considered to be an ideal tracer for 19F MRI. The described systems are designed as BAB triblock copolymers, where B corresponds to thermoresponsive PDFEA blocks and A is a hydrophilic poly(ethylene glycol) block. These BAB triblock copolymers are able to form nanoparticles in dilute aqueous solutions, which undergo a transition into physically cross-linked hydrogels upon increasing the polymer concentration. Since thermoresponsive particle- and hydrogel-based systems are applicable in a wide range of biomedical applications, we created a diagnostic system with potential therapeutic properties (theranostic) as a widely tunable platform through straightforward synthesis while serving a multitude of applications. We analyzed the effect of the BAB block ratio on the self-assembly, thermoresponsiveness, and mechanical properties of the studied hydrogels, together with their suitability for 19F MRI. Finally, their biocompatibility was assessed on a relevant cell line.
Permanent Link: https://hdl.handle.net/11104/0338351