Evaluation of multifunctional magnesium aluminosilicate materials as novel family of glidants in solid dosage products

0559344 - ÚCHP 2023 RIV GB eng J - Journal Article
Tran, D.T. - Komínová, P. - Kulaviak, Lukáš - Zámostný, P.
Evaluation of multifunctional magnesium aluminosilicate materials as novel family of glidants in solid dosage products.
International Journal of Pharmaceutics. Roč. 592, JAN 5 (2021), č. článku 120054. ISSN 0378-5173. E-ISSN 1873-3476
Institutional support: RVO:67985858
Keywords : magnesium aluminosilicate * glidant * flow properties
OECD category: Chemical process engineering
Impact factor: 6.510, year: 2021
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0378517320310395?via%3Dihub

The work was aimed at evaluating the efficiency of multifunctional magnesium aluminosilicate materials (MAS) as a novel glidant in solid dosage forms. MAS are known for their very low cohesive interactions and their utilization could avoid the disadvantages associated with conventional glidant usage. Flow properties of several mixtures comprising a model excipient (microcrystalline cellulose) and a glidant were characterized using a powder rheometer FT4. The mixtures were formulated to represent effects of glidant types, various levels of glidant loading, particle size and mixing time on flow properties of the model excipient. Pre-conditioning, shear testing, compressibility, flow energy measurements and an additional tapping test were carried out to monitor flow properties. Mixtures were analyzed employing scanning electron microscopy, using a detector of back-scattered electrons to identify a mechanism of MAS towards improving the mixture flow properties. All studied parameters were found to have substantial effects on mixture flow properties, but the effect of mixing time was much less important compared to mixtures based on traditional glidant. The mechanism of MAS glidant action was found to be different compared to that of traditional one, having less process sensitivity, so that MAS utilization as glidant could be advantageous for the formulation performance.
Permanent Link: https://hdl.handle.net/11104/0332675