Avenue to X-ray-induced photodynamic therapy of prostatic carcinoma with octahedral molybdenum cluster nanoparticles

0559289 - ÚMG 2023 RIV GB eng J - Journal Article
Koncošová, M. - Rumlová, M. - Mikyšková, Romana - Reiniš, Milan - Zelenka, J. - Ruml, T. - Kirakci, Kaplan - Lang, Kamil
Avenue to X-ray-induced photodynamic therapy of prostatic carcinoma with octahedral molybdenum cluster nanoparticles.
Journal of Materials Chemistry B. Roč. 10, č. 17 (2022), s. 3303-3310. ISSN 2050-750X. E-ISSN 2050-7518
R&D Projects: GA ČR(CZ) GA21-11688S
Institutional support: RVO:68378050 ; RVO:61388980
Keywords : cancer * BR
OECD category: Biochemistry and molecular biology; Inorganic and nuclear chemistry (UACH-T)
Impact factor: 7, year: 2022
Method of publishing: Limited access
https://pubs.rsc.org/en/content/articlelanding/2022/tb/d2tb00141a

X-Ray-induced photodynamic therapy represents a suitable modality for the treatment of various malignancies. It is based on the production of reactive oxygen species by radiosensitizing nanoparticles activated by X-rays. Hence, it allows overcoming the depth-penetration limitations of conventional photodynamic therapy and, at the same time, reducing the dose needed to eradicate cancer in the frame of radiotherapy treatment. The direct production of singlet oxygen by octahedral molybdenum cluster complexes upon X-ray irradiation is a promising avenue in order to simplify the architecture of radiosensitizing systems. One such complex was utilized to prepare water-stable nanoparticles using the solvent displacement method. The nanoparticles displayed intense red luminescence in aqueous media, efficiently quenched by oxygen to produce singlet oxygen, resulting in a substantial photodynamic effect under blue light irradiation. A robust radiosensitizing effect of the nanoparticles was demonstrated in vitro against TRAMP-C2 murine prostatic carcinoma cells at typical therapeutic X-ray doses. Injection of a suspension of the nanoparticles to a mouse model revealed the absence of acute toxicity as evidenced by the invariance of key physiological parameters. This study paves the way for the application of octahedral molybdenum cluster-based radiosensitizers in X-ray-induced photodynamic therapy and its translation to in vivo experiments.
Permanent Link: https://hdl.handle.net/11104/0332620