Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase

0557890 - FGÚ 2023 RIV NL eng J - Journal Article
Brejchová, Kristýna - Palůchová, Veronika - Březinová, Marie - Čajka, Tomáš - Balas, L. - Durand, T. - Křížová, M. - Straňák, Z. - Kuda, Ondřej
Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase.
Food Chemistry. Roč. 388, Sep 15 (2022), č. článku 132983. ISSN 0308-8146. E-ISSN 1873-7072
R&D Projects: GA ČR(CZ) GA20-00317S
Grant - others:AV ČR(CZ) LQ200111901
Program: Prémie Lumina quaeruntur
Institutional support: RVO:67985823
Keywords : human breast milk * lipidomics * PAHSA * colostrum * elective caesarean section * preterm birth
OECD category: Biochemistry and molecular biology
Impact factor: 8.8, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.foodchem.2022.132983

Breast milk is a complex mixture containing underexplored bioactive lipids. We performed an observational case-control study to compare the impact of delivery mode: caesarean section (CS) and vaginal birth (VB), and term (preterm and term delivery) on the levels of lipokines in human milk at different stages of lactation. Metabolomic analysis of the milk identified triacylglycerol estolides as a metabolic reservoir of the anti-inflammatory lipid mediator 5-palmitic acid ester of hydroxystearic acid (5-PAHSA). We found that triacylglycerol estolides were substrates of carboxyl ester lipase and 5-PAHSA-containing lipids were the least preferred substrates among tested triacylglycerol estolide isomers. This explained exceptionally high colostrum levels of 5-PAHSA in the VB group. CS and preterm birth negatively affected colostrum lipidome, including 5-PAHSA levels, but the lipidomic profiles normalized in mature milk. Mothers delivering term babies vaginally produce colostrum rich in 5-PAHSA, which could contribute to the prevention of intestinal inflammation in newborns.
Permanent Link: http://hdl.handle.net/11104/0331769