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Effects of high magnetic fields on the diffusion of biologically active molecules

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    0556091 - FZÚ 2023 RIV CH eng J - Journal Article
    Zablotskii, Vitalii - Polyakova, Tetyana - Dejneka, Alexandr
    Effects of high magnetic fields on the diffusion of biologically active molecules.
    Cells. Roč. 11, č. 1 (2022), č. článku 81. E-ISSN 2073-4409
    R&D Projects: GA MŠMT(CZ) EF16_019/0000760
    Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
    Institutional support: RVO:68378271
    Keywords : magnetic field * molecular diffusion * drug diffusion * hemoglobin * red blood cells
    OECD category: Particles and field physics
    Impact factor: 6, year: 2022
    Method of publishing: Open access

    The diffusion of biologically active molecules is a ubiquitous process, controlling many mechanisms and the characteristic time scales for pivotal processes in living cells. Here, we show how a high static magnetic field (MF) affects the diffusion of paramagnetic and diamagnetic species including oxygen, hemoglobin, and drugs. We derive and solve the equation describing diffusion of such biologically active molecules in the presence of an MF as well as reveal the underlying mechanism of the MF’s effect on diffusion. We found that a high MF accelerates diffusion of diamagnetic species while slowing the diffusion of paramagnetic molecules in cell cytoplasm. When applied to oxygen and hemoglobin diffusion in red blood cells, our results suggest that an MF may significantly alter the gas exchange in an erythrocyte and cause swelling.
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