Selective deficits in attentional set-shifting in mice induced by maternal immune activation with poly(I:C)

0555852 - FGÚ 2023 RIV NL eng J - Journal Article
Malenínská, Kristýna - Janíková, Martina - Radostová, Dominika - Vojtěchová, Iveta - Petrásek, Tomáš - Kirdajová, Denisa - Anděrová, Miroslava - Svoboda, Jan - Stuchlík, Aleš
Selective deficits in attentional set-shifting in mice induced by maternal immune activation with poly(I:C).
Behavioural Brain Research. Roč. 419, 15 Feb (2022), č. článku 113678. ISSN 0166-4328. E-ISSN 1872-7549
R&D Projects: GA ČR(CZ) GA19-03016S
Institutional support: RVO:67985823 ; RVO:68378041
Keywords : immunochallenge * poly(I:C) * maternal immune activation * cognitive deficit * schizophrenia * behavioral tests * mouse * interneurons * prenatal infection
OECD category: Neurosciences (including psychophysiology
Impact factor: 2.7, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.bbr.2021.113678

Maternal immune activation has been identified as a significant risk factor for schizophrenia. Using rodent models, past work has demonstrated various behavioral and brain impairments in offspring after immune-activating events. We applied 5 mg/kg of poly(I:C) on gestation day 9 to pregnant mouse dams, whose offspring were then stressed during puberty. We show impairments in attentional set-shifting in a T-maze, and a decreased number of parvalbumin-positive interneurons in the hippocampus as a result of peripubertal stress specifically in females.
Permanent Link: http://hdl.handle.net/11104/0330313