A complex evaluation of the in-vivo biocompatibility and degradation of an extruded ZnMgSr absorbable alloy implanted into rabbit bones for 360 days

0549687 - FZÚ 2022 RIV CH eng J - Journal Article
Klíma, K. - Ulmann, D. - Bartoš, M. - Španko, M. - Dušková, J. - Vrbová, R. - Pinc, Jan - Kubásek, J. - Vlk, M. - Ulmannová, T. - Foltán, R. - Brizman, E. - Drahoš, M. - Beňo, M. - Machoň, V. - Čapek, Jaroslav
A complex evaluation of the in-vivo biocompatibility and degradation of an extruded ZnMgSr absorbable alloy implanted into rabbit bones for 360 days.
International Journal of Molecular Sciences. Roč. 22, Dec (2021), č. článku 13444. E-ISSN 1422-0067
R&D Projects: GA MŠMT LM2018110; GA MŠMT(CZ) EF16_019/0000760; GA ČR(CZ) GA18-06110S
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : absorbable metals * in vivo * magnesium * zinc * strontium * toxicity * biocompatibility * systemic reactions * alloy accumulation * internal organs
OECD category: Materials engineering
Impact factor: 6.208, year: 2021
Method of publishing: Open access

In this study, we analyzed an extruded Zn-0.8Mg-0.2Sr (wt.%) absorbable/biodegradable alloy on a rabbit model. Screws made of this alloy were implanted into the rabbit tibia. After 120, 240, and 360 days, we tested the toxicity at the site of implantation and also within the vital organs. The results were compared with a control group, implanted with a Ti-based screw and sacrificed after 360 days. The samples were analyzed using X-ray, micro-CT, and a scanning electron microscope. Chemical analysis revealed only small concentrations of zinc, strontium, and magnesium in the liver, kidneys, and brain. Histologically, the alloy was verified to possess very good biocompatibility after 360 days. We did not observe raised levels of Sr, Zn, or Mg in any of the vital organs when compared with the Ti group at 360 days. The material was found to slowly degrade in vivo, forming solid corrosion products on its surface.
Permanent Link: http://hdl.handle.net/11104/0325631