Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease

0549312 - ÚPT 2022 RIV US eng J - Journal Article
Bočková, M. - Výtvarová, E. - Lamoš, M. - Klimeš, Petr - Jurák, Pavel - Halámek, Josef - Goldemundová, S. - Baláž, M. - Rektor, I.
Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease.
Human Brain Mapping. Roč. 42, č. 17 (2021), s. 5626-5635. ISSN 1065-9471. E-ISSN 1097-0193
R&D Projects: GA MZd(CZ) NU21-04-00445; GA ČR(CZ) GA21-25953S
Institutional support: RVO:68081731
Keywords : deep brain stimulation * high-density EEG * network analysis * subthalamic nucleus
OECD category: Clinical neurology
Impact factor: 5.399, year: 2021
Method of publishing: Open access
https://onlinelibrary.wiley.com/doi/10.1002/hbm.25642

The degree of response to subthalamic nucleus deep brain stimulation (STN-DBS) is individual and hardly predictable. We hypothesized that DBS-related changes in cortical network organization are related to the clinical effect. Network analysis based on graph theory was used to evaluate the high-density electroencephalography (HDEEG) recorded during a visual three-stimuli paradigm in 32 Parkinson's disease (PD) patients treated by STN-DBS in stimulation off and on states. Preprocessed scalp data were reconstructed into the source space and correlated to the behavioral parameters. In the majority of patients (n = 26), STN-DBS did not lead to changes in global network organization in large-scale brain networks. In a subgroup of suboptimal responders (n = 6), identified according to reaction times (RT) and clinical parameters (lower Unified Parkinson's Disease Rating Scale [UPDRS] score improvement after DBS and worse performance in memory tests), decreased global connectivity in the 1-8 Hz frequency range and regional node strength in frontal areas were detected. The important role of the supplementary motor area for the optimal DBS response was demonstrated by the increased node strength and eigenvector centrality in good responders. This response was missing in the suboptimal responders. Cortical topologic architecture is modified by the response to STN-DBS leading to a dysfunction of the large-scale networks in suboptimal responders.
Permanent Link: http://hdl.handle.net/11104/0325370