Radiobiology experiments with ultra-high dose rate laser-driven protons: methodology and state-of-the-art

0547183 - FZÚ 2022 RIV CH eng J - Journal Article
Chaudhary, P. - Milluzzo, G. - Ahmed, H. - Odložilík, Boris - McMurray, A. - Prise, K. M. - Borghesi, M.
Radiobiology experiments with ultra-high dose rate laser-driven protons: methodology and state-of-the-art.
Frontiers in Physics. Roč. 9, Apr (2021), č. článku 624963. ISSN 2296-424X. E-ISSN 2296-424X
EU Projects: European Commission(XE) 18HLT04 - UHDpulse
Research Infrastructure: ELI Beamlines III - 90141
Institutional support: RVO:68378271
Keywords : protontherapy * cancer * radiobiology * laser-driven ions * particle accelerator * ultra-high dose rate
OECD category: Fluids and plasma physics (including surface physics)
Impact factor: 3.718, year: 2021
Method of publishing: Open access

The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types of solid tumours. In particular, protons are well known for sparing normal tissues and increasing the overall therapeutic index. Recent studies show that normal tissue sparing can be further enhanced through proton delivery at 100 Gy/s and above, in the so-called FLASH regime. This has generated very significant interest in assessing the biological effects of proton pulses delivered at very high dose rates. Laser-accelerated proton beams have unique temporal emission properties, which can be exploited to deliver Gy level doses in single or multiple pulses at dose rates exceeding by many orders of magnitude those currently used in FLASH approaches. An extensive investigation of the radiobiology of laser-driven protons is therefore not only necessary for future clinical application, but also offers the opportunity of accessing yet untested regimes of radiobiology.
Permanent Link: http://hdl.handle.net/11104/0323523