Thalamic oscillatory activity may predict response to deep brain stimulation of the anterior nuclei of the thalamus

0544467 - ÚPT 2022 RIV US eng J - Journal Article
Deutschová, B. - Klimeš, Petr - Jordan, Z. - Jurák, Pavel - Erőss, L. - Lamoš, M. - Halámek, Josef - Daniel, P. - Rektor, I. - Fabo, D.
Thalamic oscillatory activity may predict response to deep brain stimulation of the anterior nuclei of the thalamus.
Epilepsia. Roč. 62, č. 5 (2021), E70-E75. ISSN 0013-9580. E-ISSN 1528-1167
R&D Projects: GA ČR(CZ) GA21-25953S
Institutional support: RVO:68081731
Keywords : anterior thalamic nucleus * deep brain stimulation * oscillations * prediction
OECD category: Clinical neurology
Impact factor: 6.740, year: 2021
Method of publishing: Limited access
https://onlinelibrary.wiley.com/doi/10.1111/epi.16883

We hypothesized that local/regional properties of stimulated structure/circuitry contribute to the effect of deep brain stimulation (DBS). We analyzed intracerebral electroencephalographic (EEG) recordings from externalized DBS electrodes targeted bilaterally in the anterior nuclei of the thalamus (ANT) in 12 patients (six responders, six nonresponders) with more than 1 year of follow-up care. In the bipolar local field potentials of the EEG, spectral power (PW) and power spectral entropy (PSE) were calculated in the passbands 1-4, 4-8, 8-12, 12-20, 20-45, 65-80, 80-200 and 200-500 Hz. The most significant differences between responders and nonresponders were observed in the BRIDGE area (bipolar recordings with one contact within the ANT and the second contact in adjacent tissue). In responders, PW was significantly decreased in the frequency bands of 65-80, 80-200, and 200-500 Hz (p < .05), PSE was significantly increased in all frequency bands (p < .05) except for 200-500 Hz (p = .06). The local EEG characteristics of ANT recorded after implantation may play a significant role in DBS response prediction.
Permanent Link: http://hdl.handle.net/11104/0321313