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Plasma-Activated Polyvinyl Alcohol Foils for Cell Growth

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    0537924 - FGÚ 2021 RIV CH eng J - Journal Article
    Kasálková-Slepičková, N. - Slepička, P. - Ivanovská, B. - Trávníčková, Martina - Malinský, Petr - Macková, Anna - Bačáková, Lucie - Švorčík, V.
    Plasma-Activated Polyvinyl Alcohol Foils for Cell Growth.
    Coatings. Roč. 10, č. 11 (2020), č. článku 1083. E-ISSN 2079-6412
    R&D Projects: GA ČR GA19-02482S
    Institutional support: RVO:67985823 ; RVO:61389005
    Keywords : cytocompatibility * nanoparticle doping * plasma treatment * polymer * PVA * surface characterization * tissue engineering
    Subject RIV: EI - Biotechnology ; Bionics; BG - Nuclear, Atomic and Molecular Physics, Colliders (UJF-V)
    OBOR OECD: Biomaterials (as related to medical implants, devices, sensors); Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect) (UJF-V)
    Impact factor: 2.881, year: 2020

    Hydrogels, and not only natural polysaccharide hydrogels, are substances capable of absorbing large amounts of water and physiological fluids. In this study, we set out to optimize the process for preparing polyvinyl alcohol (PVA) hydrogels. Subsequently, we doped PVA foils with cellulose powder, with poly(ethylene glycol) (PEG) or with gold nanoparticles in PEG colloid solutions (Au). The foils were then modified in a plasma discharge to improve their biocompatibility. The properties of PVA foils were studied by various analytical methods. The use of a suitable dopant can significantly affect the surface wettability, the roughness, the morphology and the mechanical properties of the material. Plasma treatment of PVA leads to ultraviolet light-induced crosslinking and decreasing water absorption. At the same time, this treatment significantly improves the cytocompatibility of the polymer, which is manifested by enhanced growth of human adipose-derived stem cells. This positive effect on the cell behavior was most pronounced on PVA foils doped with PEG or with Au. This modification of PVA therefore seems to be most suitable for the use of this polymer as a cell carrier for tissue engineering, wound healing and other regenerative applications.
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