Mitocans Revisited: Mitochondrial Targeting as Efficient Anti-Cancer Therapy

0535784 - BTÚ 2021 RIV CH eng J - Journal Article
Dong, L. - Gopalan, V. - Holland, O. - Neužil, Jiří
Mitocans Revisited: Mitochondrial Targeting as Efficient Anti-Cancer Therapy.
International Journal of Molecular Sciences. Roč. 21, č. 21 (2020), č. článku 7941. E-ISSN 1422-0067
Institutional support: RVO:86652036
Keywords : alpha-tocopheryl succinate * overcoming drug-resistance * cervical-cancer cells * glutamine-metabolism * mitochondrial targeting
OECD category: Biochemistry and molecular biology
Impact factor: 5.924, year: 2020
Method of publishing: Open access
https://www.mdpi.com/1422-0067/21/21/7941

Mitochondria are essential cellular organelles, controlling multiple signalling pathways critical for cell survival and cell death. Increasing evidence suggests that mitochondrial metabolism and functions are indispensable in tumorigenesis and cancer progression, rendering mitochondria and mitochondrial functions as plausible targets for anti-cancer therapeutics. In this review, we summarised the major strategies of selective targeting of mitochondria and their functions to combat cancer, including targeting mitochondrial metabolism, the electron transport chain and tricarboxylic acid cycle, mitochondrial redox signalling pathways, and ROS homeostasis. We highlight that delivering anti-cancer drugs into mitochondria exhibits enormous potential for future cancer therapeutic strategies, with a great advantage of potentially overcoming drug resistance. Mitocans, exemplified by mitochondrially targeted vitamin E succinate and tamoxifen (MitoTam), selectively target cancer cell mitochondria and efficiently kill multiple types of cancer cells by disrupting mitochondrial function, with MitoTam currently undergoing a clinical trial.
Permanent Link: http://hdl.handle.net/11104/0313739