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Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation
- 1.0535242 - MBÚ 2021 RIV CH eng J - Journal Article
Ahmad, Jawid Nazir - Šebo, Peter
Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation.
Frontiers in Immunology. Roč. 11, SEP 11 2020 (2020), č. článku 2181. ISSN 1664-3224. E-ISSN 1664-3224
R&D Projects: GA ČR(CZ) GX19-27630X
Institutional support: RVO:61388971
Keywords : dedifferentiation * Bordetella pertussis * adenylate cyclase toxin
OECD category: Immunology
Impact factor: 7.561, year: 2020
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fimmu.2020.02181/full
Circulating inflammatory monocytes are attracted to infected mucosa and differentiate into macrophage or dendritic cells endowed with enhanced bactericidal and antigen presenting capacities. In this brief Perspective we discuss the newly emerging insight into how the cAMP signaling capacity ofBordetella pertussisadenylate cyclase toxin manipulates the differentiation of monocytes and trigger dedifferentiation of the alveolar macrophages to facilitate bacterial colonization of human airways.
Permanent Link: http://hdl.handle.net/11104/0313329
Number of the records: 1