Carotid Intima-media Thickness and Laboratory Parameters of Atherosclerosis Risk in Patients with Breast Cancer

0533730 - ÚI 2021 GR eng J - Journal Article
Melichar, B. - Kalábová, H. - Ungermann, L. - Krcmová, L. - Hyšpler, R. - Kašparová, M. - Pecka, M. - Šrámek, V. - Procházková-Studentová, H. - Svobodník, A. - Pecen, Ladislav - Solichová, D.
Carotid Intima-media Thickness and Laboratory Parameters of Atherosclerosis Risk in Patients with Breast Cancer.
Anticancer Research. Roč. 32, č. 9 (2012), s. 4077-4084. ISSN 0250-7005. E-ISSN 1791-7530
Keywords : emission computed-tomography * coronary-artery-disease * long-term survivors * c-reactive protein * myocardial-infarction * cardiovascular-disease * urinary neopterin * radiation-therapy * prognostic value * inflammation * Atherosclerosis * breast cancer * intima-media thickness * cardiovascular risk
Impact factor: 1.713, year: 2012

Aim: To investigate the relation between intima-media thickness (IMT) and laboratory parameters of atherosclerosis risk in patients with breast carcinoma. Patients and Methods: IMT and a panel of laboratory parameters associated with the risk of atherosclerosis were studied in 192 patients with histologically-verified breast carcinoma. Results: Patients with metastatic disease had significantly higher fibrinogen, C-reactive protein (CRP), urinary neopterin and mean IMT, and significantly lower serum albumin and hemoglobin concentrations. Significant correlations were observed between CRP, urinary neopterin, mean IMT and other parameters of cardiovascular risk. Age was an independent predictor of the presence of sonographic signs of atherosclerosis using logistic regression, and age, glucose, time from start of chemotherapy, high-density lipoprotein cholesterol, D-dimers were independently associated with IMT in stepwise regression models. Conclusion: In addition to the associations between IMT and laboratory or clinical parameters of the risk of atherosclerosis, IMT may also be associated with the time from chemotherapy.
Permanent Link: http://hdl.handle.net/11104/0312025