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Polypeptides for the treatment of autoimmune diseases based on blocking the p19 subunit of the IL-23 human cytokine

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    0523549 - BTÚ 2020 RIV eng P - Patent Document
    Malý, Petr - Křížová, Lucie - Kuchař, Milan - Petroková, Hana
    Polypeptides for the treatment of autoimmune diseases based on blocking the p19 subunit of the IL-23 human cytokine.
    2019. Owner: Biotechnologický ústav AV ČR, v. v. i. Date of the patent acceptance: 15.05.2019. Patent Number: 307849B6
    Institutional support: RVO:86652036
    Keywords : p19 subunit * amino acids P, A, T, M, Q * IL-23 human cytokine
    OECD category: Biochemistry and molecular biology
    https://cz.espacenet.com/advancedSearch?locale=cz_CZ

    The invention concerns a polypeptide suitable for treating autoimmune diseases comprising an amino acid sequence: XYKNXINXAXXVXXVKXXIDXILAXILAXLP (SEW ID NO. 1) with an alpha-helical structure directly attached to the N-terminus or C-terminus, where: X 1 is selected from amino acids V, I, P, S ., Xis selected from amino acids T, W, R, L, M, Xis selected from amino acids P, A, T, M, Q, Xis selected from amino acids A, S, G, V, Xis selected from amino acids W, G, T, F, L, Xis selected from amino acids L, R, A, Xis selected from amino acids A, H, L, Y, R, Xis selected from amino acids R, S, Xis selected from amino acids M, C, W, R, F, Xis selected from amino acids R, M, L, S, V, Xis selected from amino acids N, A, G, P, R.
    Permanent Link: http://hdl.handle.net/11104/0307893

     
     
Number of the records: 1