Microscopic study of multifunctional drug molecule adhesion to electronic biosensors coated with diamond and gold nanoparticles

0522084 - FZÚ 2020 RIV CZ eng C - Conference Paper (international conference)
Finsterle, T. - Pilarčíková, I. - Bláhová, I.A. - Potocký, Štěpán - Kromka, Alexander - Ukraintsev, Egor - Nepovimová, E. - Musílek, K. - Kuča, K. - Rezek, B.
Microscopic study of multifunctional drug molecule adhesion to electronic biosensors coated with diamond and gold nanoparticles.
NANOCON 2018 : Conference Proceedings of the International Conference on Nanomaterials - Research & Application /10./. Ostrava: Tanger Ltd., 2019 - (Shrbená, J.), s. 380-385. ISBN 978-80-87294-89-5.
[NANOCON 2018 -International Conference on Nanomaterials - Research and Application /10./. Brno (CZ), 17.10.2018-19.10.2018]
R&D Projects: GA MŠMT LM2015087
Institutional support: RVO:68378271
Keywords : alzheimer drugs * biosensors * nanodiamonds * nanoparticles
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
https://www.nanocon.eu/files/uploads/01/NANOCON2018%20-%20Conference%20Proceedings_content.pdf

The easy and fast detection of drug content and concentration levels is demanded in biological research as well as in clinical practice. Here we study on microscopic level how nanodiamonds and gold nanoparticles interact with a multifunctional drug molecule directly on a biosensor surface. The sensors are made of interdigitated Au electrodes coated by 5 nm hydrogenated or oxidized nanodiamonds and further combined with Au colloidal nanoparticles (size 20 nm) providing nanoscale composite (spacing 100 nm). Atomic force microscopy is employed to measure local tip-surface adhesion forces and surface topography. AFM adhesion maps show that the drug binds to all types of nanoparticles and the adhesion is also significantly influenced by the substrates on which the nanoparticles are deposited. Role of local AFM tip interaction with nanostructured surface is also discussed.

Permanent Link: http://hdl.handle.net/11104/0306586