Carbon Nanomaterials for Bioimaging, Bioanalysis, and Therapy

0521416 - ÚOCHB 2020 RIV US eng M - Monography Chapter
Pramanik, Goutam - Neburková, Jitka - Vaněk, Václav - Jani, Mona - Kindermann, Marek - Cígler, Petr
Using Polymers to Enhance the Carbon Nanomaterial Biointerface.
Carbon Nanomaterials for Bioimaging, Bioanalysis, and Therapy. Hoboken: Wiley, 2019 - (Hui, Y.; Chang, H.; Dong, H.; Zhang, X.), s. 15-42. Nanocarbon Chemistry and Interfaces. ISBN 978-1-119-37345-2
R&D Projects: GA ČR(CZ) GA18-17071S; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : biomedical applications * carbon nanomaterials * covalent modification * DLVO theory * noncovalent coating * nucleic acids * polymer functionalization * stimuli‐responsive polymers
OECD category: Nano-materials (production and properties)

This chapter focuses on functionalization of carbon nanomaterials (CNMs) with polymers for biomedical applications. A classical theoretical approach based on Derjaguin‐Landau‐Verwey‐Overbeek (DLVO) theory is commonly used to predict the stability of a colloidal system. CNMs can be functionalized with polymers via two types of approaches: noncovalent coating and covalent modification. The physicochemical properties of CNMs are determined by their intrinsic nanostructure. The chapter discusses the effect of polymer functionalization on the spectral properties of various CNMs. Stimuli‐responsive polymers respond to their environment by changing their physical and/or chemical properties. Among stimuli‐responsive polymers, thermoresponsive polymers have been exploited most abundantly to modify carbon nanoparticles. The development of nonviral, nonimmunogenic, and biocompatible vectors for efficient intracellular transfection of nucleic acids (NAs) is one of the challenges facing future gene therapy approaches. The surface of the CNMs can be functionalized by covalent or noncovalent attachment of macromolecular layers to create reliable nonviral gene delivery vectors.
Permanent Link: http://hdl.handle.net/11104/0306045