Curcumin- and fish oil-loaded spongosome and cubosome nanoparticles with neuroprotective potential against H.sub.2./sub.O.sub.2./sub.-induced oxidative stress in differentiated human SH-SY5Y cells

0521339 - FZÚ 2020 RIV US eng J - Journal Article
Rakotoarisoa, M. - Angelov, Borislav - Garamus, V.M. - Angelova, A.
Curcumin- and fish oil-loaded spongosome and cubosome nanoparticles with neuroprotective potential against H₂O₂-induced oxidative stress in differentiated human SH-SY5Y cells.
ACS Omega. Roč. 4, č. 2 (2019), s. 3061-3073. ISSN 2470-1343. E-ISSN 2470-1343
R&D Projects: GA MŠMT LQ1606
Institutional support: RVO:68378271
Keywords : liquid-crystalline phases * solid lipid nanoparticles * blood-brain-barrier * x-ray-scattering * alzheimers-disease * drug-delivery * neurodegenerative diseases
OECD category: Fluids and plasma physics (including surface physics)
Impact factor: 2.870, year: 2019
Method of publishing: Open access

Many phytochemical antioxidant compounds, including curcumin (CU), are water-insoluble and thus require delivery carriers in order to increase their bioavailability for in vivo applications. Oxidative stress-related apoptosis is a common cause for the neuronal loss in the progression of neurodegenerative diseases. Lipid nanoparticles (NPs) with internal self-assembled liquid crystalline structures present strong interest as safe drug delivery systems for neuronal regeneration through combination therapies. Here, we report spongosome and cubosome lipid NPs, which co-encapsulate CU and fish oil (FO), rich in omega-3 polyunsaturated fatty acids. The performed structural investigation by synchrotron small-angle X-ray scattering evidenced the liquid crystalline organization of the self-assembled NPs. The encapsulation efficiency for CU in the lipid nanocarriers was found to be higher as compared to that reported for polymer-based carriers.
Permanent Link: http://hdl.handle.net/11104/0305968