Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis

0510897 - BFÚ 2020 RIV US eng J - Journal Article
Beauvarlet, J. - Mergny, Jean-Louis - Djavaheri-Mergny, M.
Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis.
Molecular & Cellular Oncology. Roč. 6, č. 4 (2019), č. článku e1604047. ISSN 2372-3556
R&D Projects: GA MŠMT EF15_003/0000477
Institutional support: RVO:68081707
Keywords : autophagy * damage * Cancer therapy * G-quadruplex * autophagy
OECD category: Oncology
Method of publishing: Limited access
https://www.tandfonline.com/doi/full/10.1080/23723556.2019.1604047

G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.
Permanent Link: http://hdl.handle.net/11104/0301264