Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests

0508104 - BC 2020 RIV US eng J - Journal Article
Meccariello, A. - Salvemini, M. - Primo, P. - Hall, B. - Koskinioti, P. - Dalíková, Martina - Gravina, A. - Gucciardino, M. A. - Forlenza, F. - Gregoriou, M.-E. - Ippolito, D. - Monti, S. M. - Petrella, V. - Perrotta, M. M. - Schmeing, S. - Ruggiero, A. - Scolari, F. - Giordino, E. - Tsoumani, K. T. - Marec, František - Windibichler, N. - Arunkumar, K. P. - Bourtzis, K. - Mathiopoulos, K. D. - Ragoussis, J. - Vitaglino, L. - Tu, Z. - Papathanos, P. A. - Robinson, M. D. - Saccone, G.
Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests.
Science. Roč. 365, č. 6460 (2019), s. 1457-1460. ISSN 0036-8075. E-ISSN 1095-9203
R&D Projects: GA ČR(CZ) GA17-13713S
Grant - others:GA ČR(CZ) GA17-17211S
Institutional support: RVO:60077344
Keywords : medfly * male sex determination * Y chromosome
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 41.846, year: 2019
Method of publishing: Limited access
https://science.sciencemag.org/content/365/6460/1457

In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, Medfly) we identified a Y-linked gene, Maleness-on the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Y chromosome can be transmitted by XY females. MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.
Permanent Link: http://hdl.handle.net/11104/0300857