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Analysis and Detection of Scytophycin Variants by HPLC-ESI-MS

  1. 1.
    0507334 - MBÚ 2020 RIV US eng J - Journal Article
    Tomšíčková, J. - Ondřej, M. - Černý, J. - Hrouzek, Pavel - Kopecký, Jan
    Analysis and Detection of Scytophycin Variants by HPLC-ESI-MS.
    Chemistry of Natural Compounds. Roč. 49, č. 6 (2014), s. 1170-1171. ISSN 0009-3130. E-ISSN 1573-8388
    R&D Projects: GA MŠMT ED2.1.00/03.0110; GA MŠMT(CZ) LH11129
    Institutional support: RVO:61388971
    Keywords : cytanobacteria
    OECD category: Microbiology
    Impact factor: 0.509, year: 2014
    Method of publishing: Limited access

    A significant number of cyanobacteria possess interesting biological activities, including cytotoxic [1] and, rarely,
    fungicidal [2]. One of the most potent group of this are scytophycins, found in cyanobacteria of the family Scytonemataceae
    30 years ago [3]. The best known representative of the scytophycin family, tolytoxin (6-hydroxy-7-O-methylscytophycin B),
    was first isolated from a terrestrial blue-green alga Tolypothrix conglutinata [4]. The genus Nostoc is a rich source of various
    bioactive metabolites, but scytophycins were never observed to be produced by this cyanobacterium.
    In this study we apply LCMSn instrumentation in order to extend its applicability for structural analysis of the scytophycin
    family members.

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