New Ligands for Modification of DNA by Osmium Tetroxide Reagents

0506683 - BFÚ 2020 RIV CZ eng C - Conference Paper (international conference)
Havran, Luděk - Zenka, Martin - Fojta, Miroslav
New Ligands for Modification of DNA by Osmium Tetroxide Reagents.
XXXVI. Moderní elektrochemické metody. Sborník přednášek. Ústí nad Labem: Best servis, 2016 - (Navrátil, T.; Fojta, M.; Schwarzová, K.), Č. 2016 (2016), s. 68-70. ISBN 978-80-905221-4-5.
[Moderní elektrochemické metody /36./. Jetřichovice (CZ), 23.05.2016-27.05.2016]
R&D Projects: GA ČR GBP206/12/G151
Institutional support: RVO:68081707
Keywords : nucleic-acids * complexes * dna * Osmium tetroxide complexes
OECD category: Physical chemistry

Besides DNA intrinsic electroactivity, modification of DNA by redox active tags find wide use in electrochemical analysis of DNA interactions and damage. Application of these tags can improve specificity of the analysis. One from utilized labels in this field are complexes of osmium tetroxide with nitrogen ligands, which produce with DNA electroactive covalent adducts. These complexes preferentially react with thymine in single strand DNA. Type of used ligand influence electrochemical behavior forming adducts. In this contribution will be presented results which are acquired by testing of set a new ligands based of quinone and substituted 1, 10-phenanthroline.
Permanent Link: http://hdl.handle.net/11104/0297880