Changing effect of GABA B receptor antagonist CGP46381 after status epilepticus in immature rats

0504234 - FGÚ 2020 RIV NL eng J - Journal Article
Mareš, Pavel - Kubová, Hana
Changing effect of GABA B receptor antagonist CGP46381 after status epilepticus in immature rats.
Epilepsy Research. Roč. 149, Jan (2019), s. 17-20. ISSN 0920-1211. E-ISSN 1872-6844
R&D Projects: GA ČR(CZ) GA15-16605S; GA ČR(CZ) GA18-09296S
Institutional support: RVO:67985823
Keywords : status epilepticus * immature rats * pentylenetetrazol * CGP46381
OECD category: Neurosciences (including psychophysiology
Impact factor: 2.208, year: 2019
Method of publishing: Limited access
https://doi.org/10.1016/j.eplepsyres.2018.11.001

Possible proconvulsant action of GABAB receptor antagonist CGP46381 was studied 3 and 13 days after status epilepticus elicited in 12-day-old rats. GABAA-dependent activity was tested by pentylenetetrazol administration and found different in 15-day-old rats after status epiolepticus but not in the older group. The interaction of the two GABAergic systems should be studied in detail.
Permanent Link: http://hdl.handle.net/11104/0295918