Do different nuclei in a binucleated cardiomyocyte have different rates of nuclear protein import?

0503879 - FGÚ 2020 RIV GB eng J - Journal Article
Hlaváčková, Markéta - Kardami, E. - Fandrich, R. - Pierce, G. N.
Do different nuclei in a binucleated cardiomyocyte have different rates of nuclear protein import?
Journal of Molecular and Cellular Cardiology. Roč. 126, JAN (2019), s. 140-142. ISSN 0022-2828. E-ISSN 1095-8584
Institutional support: RVO:67985823
Keywords : nucleus * nucleocytoplasmic trafficking * binuclear cell * cardiomyocytes * nuclear protein import
OECD category: Physiology (including cytology)
Impact factor: 4.133, year: 2019
Method of publishing: Limited access
https://doi.org/10.1016/j.yjmcc.2018.08.030

The functional significance of having two nuclei in a cell is unknown. Having two stores of genetic material may be advantageous for cell growth. Nuclear protein import is at a critical juncture in the cell to modify cell growth. This study addressed the potential for differential nuclear protein import in two nuclei of the same cell. Isolated adult rat cardiomyocytes were microinjected with an exogenous fluorescent protein conjugated with nuclear localization amino acid sequences to facilitate nuclear import and its detection. Our results demonstrate the rate of nuclear protein import was not significantly different between the two nuclei in the same cell. These data demonstrate that the two nuclei are functionally similar in a binucleated cardiomyocyte, at least as far as nucleocytoplasmic transport is concerned.
Permanent Link: http://hdl.handle.net/11104/0295651