Functional Evolution of Subolesin/Akirin

0497446 - BC 2019 RIV CH eng J - Journal Article
Artigas-Jerónimo, S. - Villar, M. - Cabezas-Cruz, A. - Valdés, James J. - Estrada-Pena, A. - Alberdi, P. - de la Fuente, J.
Functional Evolution of Subolesin/Akirin.
Frontiers in Physiology. Roč. 9, NOV 13 (2018), č. článku 1612. ISSN 1664-042X. E-ISSN 1664-042X
Grant - others:Ministerio de Economía, Industria y Competitividad(ES) BFU2016- 79892-P; Veterinary Research Institute, Brno(CZ) RO0516
Institutional support: RVO:60077344
Keywords : immune response * vaccine * interactome * regulome * phylogeny * tick * Anaplasma phagocytophilum
OECD category: Biochemical research methods
Impact factor: 3.201, year: 2018
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fphys.2018.01612/full

The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent results on their structure, protein-protein interactions and function in different species to provide insights into the functional evolution of these regulatory proteins, and their potential as vaccine antigens for the control of ectoparasite infestations and pathogen infection. The results suggest that Subolesin/Akirin evolved conserving not only its sequence and structure, but also its function and role in cell interactome and regulome in response to pathogen infection and other biological processes. This functional conservation provides a platform for further characterization of the function of these regulatory proteins, and how their evolution can meet species-specific demands. Furthermore, the conserved functional evolution of Subolesin/Akirin correlates with the protective capacity shown by these proteins in vaccine formulations for the control of different arthropod and pathogen species. These results encourage further research to characterize the structure and function of these proteins, and to develop new vaccine formulations by combining Subolesin/Akirin with interacting proteins for the control of multiple ectoparasite infestations and pathogen infection.
Permanent Link: http://hdl.handle.net/11104/0290036